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Description
CD59 Mouse mAb (S-936-1)Product Specification Host Mouse Antigen CD59 Synonyms CD59 glycoprotein; 1F5 antigen; 20 kDa homologous restriction factor (HRF 20; HRF20); MAC inhibitory protein (MAC IP); MEM43 antigen; Membrane attack complex inhibition factor (MACIF); MIC11; MIN1; MIN2; MIN3; MSK21 Immunogen Recombinant Protein Location Secreted, Cell membrane Accession P13987 Clone Number S 936 1 Antibody Type Mouse mAb Isotype IgG1,k Application WB, IHC P Reactivity Hu Positive
Product Specification
| Host | Mouse |
| Antigen | CD59 |
| Synonyms | CD59 glycoprotein; 1F5 antigen; 20 kDa homologous restriction factor (HRF-20; HRF20); MAC-inhibitory protein (MAC-IP); MEM43 antigen; Membrane attack complex inhibition factor (MACIF); MIC11; MIN1; MIN2; MIN3; MSK21 |
| Immunogen | Recombinant Protein |
| Location | Secreted, Cell membrane |
| Accession | P13987 |
| Clone Number | S-936-1 |
| Antibody Type | Mouse mAb |
| Isotype | IgG1,k |
| Application | WB, IHC-P |
| Reactivity | Hu |
| Positive Sample | HeLa, HT-1080, U-87 MG, HT-29 |
| Purification | Protein G |
| Concentration | 2 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:1000 | Hu |
| IHC-P | 1:2000 | Hu |
Background
CD59, also known as protectin or membrane attack complex inhibitory factor (MACIF), is a glycosylphosphatidylinositol (GPI)-anchored membrane protein that plays a crucial role in regulating the complement system. It is widely expressed in most human tissues and acts as a major inhibitor of the membrane attack complex (MAC) formation. The mature CD59 protein consists of 77 amino acids and is anchored to the cell membrane via a GPI anchor. By binding to complement proteins C8 and C9, CD59 prevents the assembly of the MAC, thereby protecting host cells from complement-mediated lysis. Deficiencies in CD59 expression can lead to serious disorders such as paroxysmal nocturnal hemoglobinuria (PNH), characterized by the destruction of red blood cells. Additionally, CD59 is involved in T cell signal transduction and has been implicated in various diseases, including cancer and autoimmune disorders.
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