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Description
SDHA Recombinant Rabbit mAb (S-1458-43)Product Specification Host Rabbit Antigen SDHA Synonyms Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial; Flavoprotein subunit of complex II (Fp); Malate dehydrogenase [quinone] flavoprotein subunit; SDH2; SDHF Immunogen Synthetic Peptide Location Mitochondrion Accession P31040 Clone Number S 1458 43 Antibody Type Recombinant mAb Isotype IgG Application WB, IHC P Reactivity Hu, Ms, Rt Positive Sample HepG2, Jurkat, HT 1080,
Product Specification
| Host | Rabbit |
| Antigen | SDHA |
| Synonyms | Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial; Flavoprotein subunit of complex II (Fp); Malate dehydrogenase [quinone] flavoprotein subunit; SDH2; SDHF |
| Immunogen | Synthetic Peptide |
| Location | Mitochondrion |
| Accession | P31040 |
| Clone Number | S-1458-43 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | WB, IHC-P |
| Reactivity | Hu, Ms, Rt |
| Positive Sample | HepG2, Jurkat, HT-1080, HeLa, MCF7, mouse kidney, rat kidney |
| Purification | Protein A |
| Concentration | 0.5 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:1000 | Hu, Ms, Rt |
| IHC-P | 1:250 | Hu, Ms, Rt |
Background
SDHA protein, encoded by the SDHA gene, is a crucial component of the succinate dehydrogenase complex, which is involved in the mitochondrial respiratory chain and the citric acid cycle. This protein acts as a catalytic subunit, facilitating the conversion of succinate to fumarate and transferring electrons to the oxidative phosphorylation pathway. It contains a covalently attached flavin adenine dinucleotide (FAD) cofactor, which is essential for its enzymatic activity. Mutations in the SDHA gene can lead to various disorders, including mitochondrial complex II deficiency, Leigh syndrome, and paraganglioma-pheochromocytoma syndrome. These mutations may result in impaired mitochondrial function, reduced ATP production, and the accumulation of succinate, which can disrupt cellular metabolism and contribute to disease development.
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