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Description
Cyclin A2 Recombinant Rabbit mAb (S-2554-2)Product Specification Host Rabbit Antigen Cyclin A2 Synonyms Cyclin A2; Cyclin A; Cyclin A; CCN1; CCNA; CCNA2 Immunogen Recombinant Protein Location Cytoplasm, Nucleus Accession P20248 Clone Number S 2554 2 Antibody Type Recombinant mAb Isotype IgG Application WB, IHC P, ICC Reactivity Hu Positive Sample Jurkat, K562, MCF7, SW480, HEK 293, HeLa Purification Protein A Concentration 0. 5 mg ml Conjugation Unconjugated Physical Appearance Liquid Storage
Product Specification
| Host | Rabbit |
| Antigen | Cyclin A2 |
| Synonyms | Cyclin-A2; Cyclin-A; Cyclin A; CCN1; CCNA; CCNA2 |
| Immunogen | Recombinant Protein |
| Location | Cytoplasm, Nucleus |
| Accession | P20248 |
| Clone Number | S-2554-2 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | WB, IHC-P, ICC |
| Reactivity | Hu |
| Positive Sample | Jurkat, K562, MCF7, SW480, HEK-293, HeLa |
| Purification | Protein A |
| Concentration | 0.5 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:1000-1:5000 | Hu |
| IHC-P | 1:250 | Hu |
| ICC | 1:500 | Hu |
Background
Cyclin A2 is a pivotal regulatory protein that orchestrates S-phase progression and the G2/M transition by binding and activating cyclin-dependent kinases Cdk2 and Cdk1, thereby phosphorylating substrates that initiate DNA replication origin firing, centrosome maturation, and chromosomal condensation; its expression rises during late G1, peaks in S and G2, and is abruptly degraded via APC/C-mediated ubiquitination in prometaphase to prevent premature mitotic exit, and deregulation—through gene amplification, transcriptional upregulation, or impaired destruction—drives genomic instability and oncogenesis, making it both a biomarker and therapeutic target in multiple cancers.
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