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Description
HIF-1 alpha Recombinant Rabbit mAb (S-3123)Product Specification Host Rabbit Antigen HIF 1 Synonyms Hypoxia inducible factor 1 alpha; HIF 1 alpha; HIF1 alpha; ARNT interacting protein; Basic helix loop helix PAS protein MOP1; Class E basic helix loop helix protein 78 (bHLHe78); Member of PAS protein 1; PAS domain containing protein 8; BHLHE78; MOP1; PASD8; HIF1A Location Cytoplasm, Nucleus Accession Q16665 Clone Number S 3123 Antibody Type Recombinant mAb Isotype IgG Application WB, ICC
Product Specification
| Host | Rabbit |
| Antigen | HIF-1α |
| Synonyms | Hypoxia-inducible factor 1-alpha; HIF-1-alpha; HIF1-alpha; ARNT-interacting protein; Basic-helix-loop-helix-PAS protein MOP1; Class E basic helix-loop-helix protein 78 (bHLHe78); Member of PAS protein 1; PAS domain-containing protein 8; BHLHE78; MOP1; PASD8; HIF1A |
| Location | Cytoplasm, Nucleus |
| Accession | Q16665 |
| Clone Number | S-3123 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | WB, ICC |
| Reactivity | Hu, Ms, Rt |
| Purification | Protein A |
| Concentration | 0.5 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:1000 | Hu |
| ICC | 1:500 | Hu |
Background
HIF-1α (hypoxia-inducible factor-1 alpha) is a crucial transcriptional regulator encoded by the HIF1A gene, playing a vital role in cellular adaptation to low-oxygen conditions. Under normal oxygen levels, HIF-1α has a short half-life and is rapidly degraded via the von Hippel-Lindau tumor suppressor gene product (pVHL)-mediated ubiquitin-proteasome pathway. However, in hypoxic conditions (when oxygen levels are below 5%), HIF-1α becomes stable, accumulates, and translocates to the nucleus. There, it forms an active HIF-1 complex by binding with HIF-1β, which then binds to hypoxia response elements (HRE) in the promoters of target genes, activating the transcription of over 40 genes involved in processes such as oxygen transport, glucose metabolism, cell survival, and angiogenesis. HIF-1α is highly expressed in many tissues, especially in the kidneys and heart, and is often overexpressed in various cancers, contributing to tumor growth and resistance to therapies. Its stability and activity are regulated by various post-translational modifications, including hydroxylation, acetylation, and phosphorylation.
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